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High-density lipoprotein (HDL) protects against atherosclerotic vascular disease and low high-density lipoprotein-cholesterol (HDL-C) is an important risk factor for coronary heart disease. Multilevel modeling showed that the highest tertile of HDL‐C was associated with better executive function z‐scores than the lowest tertile of HDL‐C at all time‐points. High-density lipoprotein (HDL) is the most complex class of lipoproteins. [Google Scholar] 7. High-density lipoprotein (HDL) has several potential antiatherogenic effects and protective effects on endothelial cells. 78. 2011; 364:127–135. Clinical trials aimed at increasing high-density lipoprotein (HDL)-cholesterol in secondary prevention have resulted disappointing. Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function. HDL plays a primary role in the removal of excess cholesterol from cells and returning… HDL is made in the liver and in the intestines. To understand HDL’s role in patients with Alzheimer’s disease (AD), we analyzed the chemical properties and function. Dunbar RL, Rader DJ. Journal of clinical lipidology. It attracts particular attention because, in contrast with other lipoproteins, as many physiological functions of HDL influence the cardiovascular system in favourable ways unless HDL is modified pathologically. doi: 10.1056/NEJMoa1001689. HDL, or high-density lipoprotein, is the "good" cholesterol. Conclusions. Oxidative modifications have been proposed for alteration and deterioration of HDL. High-density lipoprotein (HDL) plays a vital role in lipid metabolism and anti-inflammatory activities; a dysfunctional HDL impairs cholesterol efflux pathways. high-density lipoprotein - a lipoprotein that transports cholesterol in the blood; composed of a high proportion of protein and relatively little cholesterol; high levels are thought to be associated with decreased risk of coronary heart disease and atherosclerosis High-density lipoprotein function recent advances. 2013; 128: 1256-1267. Impaired antioxidant activity of high‐density lipoprotein in chronic kidney disease. "Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux". Gaidukov L. Tawfik D.S. Journal of Internal Medicine. LDL (low-density lipoprotein), sometimes called “bad” cholesterol, makes up most of your body’s cholesterol. In healthy individuals, about thirty percent of blood cholesterol is carried by HDL .. 2009; 153:77–85. HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. High-density lipoprotein (HDL) is one of the major carriers of cholesterol in the blood. Rohatgi A. HDL cholesterol efflux … One of the important functions of HDL is to transport cholesterol from the cells and tissue back to the liver. It is responsible for carrying cholesterol from cells back to the liver. Circulation. Introduction. Although High Density Lipoprotein Cholesterol (HDL-C) levels are inversely proportional to cardiovascular risk in many studies, recent pharmacological interventional studies with HDL-C raising strategies did not show a benefit in terms of vascular events. HDL also removes cholesterol deposited in the walls of blood vessels. The resulting high density gives this class its name. 120 (21): 2095–104. Higher high‐density lipoprotein cholesterol (HDL‐C) was associated with better executive performance at month 27 (β = 0.359, P < 0.001). HDL is comprised of several subclasses that are different in size, protein and lipid composition, physiological functions, and pathophysiological significance. Jung KY,Ahn HY,Han SK,Park YJ,Cho BY,Moon MK, Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function. Circulation . November 2020; International Journal of Molecular Sciences 21(23):8985; DOI: 10.3390/ijms21238985. The cholesterol transported in high-density lipoprotein (HDL) is called 'good' cholesterol. [Google Scholar] 8. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. 2011; 364:127–135. Assmann G, Nofer JR. Atheroprotective effects of high-density lipoproteins. 2008; 263:256–273. High-density lipoprotein cholesterol (HDL-c) has long been referred to as ‘good cholesterol’ due to its apparent inverse relationship with future CVD risk. Current Drug Options for Raising HDL Cholesterol. 2003; 54:321–41. Crossref; PubMed; Scopus (136) Google Scholar; This enzyme, present mostly in the HDL particle, is activated by binding to apoA-I. RESEARCH Open Access Effect of niacin monotherapy on high density lipoprotein composition and function Scott M. Gordon1*†, Marcelo J. Amar2†, Kianoush Jeiran2, Michael Stagliano2, Emma Staller2, Martin P. Playford3, Nehal N. Mehta3, Tomas Vaisar4 and Alan T. Remaley2 Abstract Background: Niacin has modest but overall favorable effects on plasma lipids by increasing high density Furthermore, studies have reported on the negative impact of cardiovascular disease on HDL composition and function. Among these, dyslipidemia characterized by a low level of HDL-C (high-density lipoprotein cholesterol) ... Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effects of high density lipoproteins. Abnormal function of high‐density lipoprotein (HDL) has been implicated as a potential mechanism for the increased incidence of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA). The structures and cholesterol transport abilities of HDL particles are determined by the properties of their exchangeable apolipoprotein (apo) components. Other articles where High-density lipoprotein is discussed: lipid: High-density lipoproteins (HDL): Lipoproteins of this class are the smallest, with a diameter of 10.8 nm and the highest protein-to-lipid ratio. Crossref Medline Google Scholar; 43. Crossref Medline Google Scholar; 44 Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V. Dysfunctional high‐density lipoprotein in patients on chronic hemodialysis. High-density lipoprotein cholesterol levels are inversely associated with coronary heart disease and other forms of vascular disease. High-Density Lipoprotein (HDL) Compared to LDL, HDL consists of less cholesterol and more protein, making these lipoproteins the densest. The HDL particle is heterogenous with anti-atherogenic functions and non-vascular effects. Apart from transferring excess cholesterol to the liver, high-density lipoprotein exhibits favorable effects on oxidation, inflammation, thrombosis and endothelial function. New England Journal of Medicine. Annu Rev Med. Les lipoprotéines de haute densité (high density lipoprotein, HDL) sont des lipoprotéines responsables du transport du cholestérol vers le foie où il pourra être éliminé. 5 Many studies have described an inverse association between high-density lipoprotein concentration and cardiovascular events. 1 Following a ‘the higher, the better’ view, clinical and scientific concepts strongly focused on the quantity of HDL for a long time. DM is an idiopathic inflammatory myopathy (IIM) that is associated with marked activation and damage to small blood vessels in connective tissue of the muscle, skin and gastrointestinal tract [1, 2]. Tall A.R. Their most described function is to mediate the reverse transport of cholesterol, from peripheral tissues back to the liver. 79. High levels of LDL cholesterol raise your risk for heart disease and stroke. J Am Coll Cardiol. Transl Res. Therefore abnormal and reduced vasoprotective effects of HDL are closely associated with atherogenesis and an increased risk of cardiovascular disease. N Engl J Med. Les lipoprotéines de haute densité (high density lipoprotein, HDL) sont des lipoprotéines responsables du transport du cholestérol vers le foie où il pourra être éliminé. High-density lipoprotein (HDL) is one of the five major groups of lipoproteins (chylomicrons, VLDL, IDL, LDL, HDL) which enable lipids like cholesterol and triglycerides to be transported within the water based blood stream. 2005; 46 (10):1792–8. High-Density Lipoprotein Function: Recent Advances Benjamin J. Ansell, Karol E. Watson, Alan M. Fogelman, Mohamad Navab, Gregg C. Fonarow Recent research has elucidated mechanisms of atheroprotective roles of high-density lipoprotein (HDL) along with circumstances and individuals in which HDL can become paradoxically proinflammatory. The High Density Lipoprotein and Endothelial Function, Niacin and Nitric Oxide Study (The High-Ennd Study) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. It helps to remove bad cholesterol from your arteries, so a higher HDL level is better. Impaired high-density lipoprotein antioxidant function was associated with higher idiopathic inflammatory myopathy disease activity and dermatomyositis diagnosis. Because of this, HDL is also considered the “good” cholesterol. Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. 2017 Nov - Dec; [PubMed PMID: 28958565] Kronenberg F, High-density lipoprotein cholesterol on a roller coaster: where will the ride end? 37. Read our disclaimer for details. The anti-inflammatory and proinflammatory … High-Density Lipoprotein Function Recent Advances Benjamin J. Ansell, MD, FACC, Karol E. Watson, MD, PHD, Alan M. Fogelman, MD, FACC, Mohamad Navab, PHD, Gregg C. Fonarow, MD, FACC Los Angeles, California Although high-density lipoproteins (HDL) possess many features that contribute to the association between elevated HDL cholesterol and protection from atherosclerosis, these lipoproteins … Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function Kyong Yeun Jung, Hwa Young Ahn, Sun Kyoung Han, Young Joo Park , … High HDL-cholesterol is good as it takes cholesterol out of cells and the blood and helps to prevent excess cholesterol. Khera A.V. High density lipoprotein (HDL) possesses important anti-atherogenic properties and this review addresses the molecular mechanisms underlying these functions. High-density lipoprotein (HDL) particles have a broad spectrum of antiatherogenic properties including efflux of cellular cholesterol, vasodilation, reduction of apoptosis, anti-inflammatory effects and diminishing platelet activation. 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